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#47 How to improve metabolic health | A gene expression approach


This case study focuses on a 48-year-old woman grappling with weight management issues, fatigue, and sporadic mood swings.

Her sedentary lifestyle and preference for high-sugar, processed foods have exacerbated her health concerns. She reports frequent bouts of lethargy and mood instability. Her family history includes Type 2 diabetes and cardiovascular diseases.

Through our advanced transcriptomic testing, we identified significant disturbances in her metabolic pathways. Join us to learn how a customized intervention plan, based on her unique transcriptomic profile, aided her in addressing these challenges.

Challenges Faced:

Before conducting the transcriptomic analysis, the patient shared several key issues:

  • Persistent weight gain: Despite various diet attempts, she struggled with continuous weight gain.
  • Fluctuating energy levels: She experienced high energy spikes followed by extreme fatigue, correlating with her dietary habits.
  • Mood swings: Periods of irritability and sadness were frequent, affecting her daily life and relationships.

Detected Metabolic Alterations:

Our transcriptomic analysis revealed notable imbalances in the following metabolic pathways:

  • Insulin signaling pathway: Crucial for glucose homeostasis and affected by high sugar diets, leading to insulin resistance.
  • Pentose phosphate pathway: Vital for maintaining cellular redox balance; disruption can lead to oxidative stress.
  • Steroid biosynthesis: Imbalances here can affect hormonal levels, impacting mood and metabolism.
  • Tryptophan metabolism: Directly linked to serotonin production, influencing mood and sleep patterns.

Proposed Solution for Improving Altered Pathways:

  • Insulin signaling pathway: Implement a low-glycemic diet to stabilize blood sugar levels and enhance insulin sensitivity.
  • Pentose phosphate pathway: Increase antioxidant-rich foods, such as berries, nuts, and green leafy vegetables, to combat oxidative stress.
  • Steroid biosynthesis: Balance hormonal levels by including foods rich in phytoestrogens and omega-3 fatty acids.
  • Tryptophan metabolism: Encourage the consumption of tryptophan-rich foods like turkey, oats, and bananas to support serotonin production.

Recovery Strategy:

Dietary and Lifestyle Modifications:

  • Adopt a balanced diet, focusing on whole foods, lean proteins, and complex carbohydrates to improve overall metabolic health.
  • Introduce regular physical activity, starting with low-impact exercises like walking or swimming, to boost metabolism and mood.
  • Reduce processed and high-sugar foods to lower the risk of insulin resistance and improve energy levels.

Key Supplements:

  • Magnesium: To support insulin action and reduce sugar cravings. Take 300-400 mg daily.
  • Omega-3 fatty acids: For their anti-inflammatory properties and to support hormonal balance. Take 1-2g daily.
  • Vitamin B complex: To aid in energy production and stabilize mood. Take as per recommended dosage.
  • 5-HTP: A precursor to serotonin, to aid in mood stabilization and improve sleep quality. Take 100-300 mg before bedtime, as advised by a healthcare professional.

Results and Final Assessment:

After 6 months of following the tailored plan, we observed significant improvements in her metabolic pathways. The patient reported a steady weight loss, enhanced energy levels, and more stable moods. She stated: “I can’t believe the difference in how I feel! My energy is consistent throughout the day, and my mood has improved dramatically. I feel more in control of my health now.”

This case exemplifies the transformative power of personalized health interventions based on transcriptomic analysis, particularly in improving metabolic health and overall well-being.

For more information about our transcriptomic research and personalized health plans, please contact us at info@beyondyou.life. Our team of experts is ready to assist you with your health and wellness needs.

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